PCR DETECTION OF STRUCTURALLY ABNORMAL Y-CHROMOSOMES

被引：29

作者：

NAGAFUCHI, S

SEKI, S

NAKAHORI, Y

TAMURA, T

NUMABE, H

NAKAGOME, Y

机构：

[1] UNIV TOKYO,SCH INT HLTH,DEPT HUMAN GENET,BUNKYO KU,TOKYO 113,JAPAN

[2] NATL CHILDRENS MED RES CTR,DEPT CONGENITAL ABNORMAL RES,SETAGAYA KU,TOKYO 154,JAPAN

[3] KYORIN UNIV,SCH HLTH SCI,DEPT CLIN GENET,TOKYO 192,JAPAN

[4] TOKYO MED COLL,DEPT PEDIAT,SHINJUKU KU,TOKYO 160,JAPAN

来源：

JAPANESE JOURNAL OF HUMAN GENETICS | 1992年 / 37卷 / 03期

关键词：

PCR; STS; Y-CHROMOSOME; DELETION MAPPING;

D O I：

10.1007/BF01900712

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Three probes each detecting a locus on the proximal long arm of the Y chromosome were partially sequenced. Thus, 3 sets of novel primers were developed which enable PCR detection of these 3 loci. Five previously reported primer sets, 3 on the short arm and each one on the centromere and the distal long arm, were mapped along with the novel three using a mapping panel consisted of 8 patients each with different structural abnormality of the Y chromosome. Now, PCR detection of these 8 loci covering an entire length of the Y chromosome has become possible enabling rapid screening of patients with Y chromosome aberrations.

引用

页码：187 / 193

页数：7

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