DESIGN AND SYNTHESIS OF PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE AND RENIN - EVIDENCE FOR IMPROVED TRANSPORT

被引:79
作者
SMITH, AB
HIRSCHMANN, R
PASTERNAK, A
AKAISHI, R
GUZMAN, MC
JONES, DR
KEENAN, TP
SPRENGELER, PA
DARKE, PL
EMINI, EA
HOLLOWAY, MK
SCHLEIF, WA
机构
[1] MERCK SHARP & DOHME LTD,RES LABS,DEPT MOLEC BIOL,W POINT,PA 19486
[2] MERCK SHARP & DOHME LTD,RES LABS,DEPT VIRUS & CELL BIOL,W POINT,PA 19486
[3] MERCK SHARP & DOHME LTD,RES LABS,DEPT MOLEC SYST,W POINT,PA 19486
关键词
D O I
10.1021/jm00028a001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:215 / 218
页数:4
相关论文
共 39 条
  • [1] RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE
    BOGER, J
    PAYNE, LS
    PERLOW, DS
    LOHR, NS
    POE, M
    BLAINE, EH
    ULM, EH
    SCHORN, TW
    LAMONT, BI
    LIN, TY
    KAWAI, M
    RICH, DH
    VEBER, DF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) : 1779 - 1790
  • [2] THE INFLUENCE OF PEPTIDE STRUCTURE ON TRANSPORT ACROSS CACO-2 CELLS
    CONRADI, RA
    HILGERS, AR
    HO, NFH
    BURTON, PS
    [J]. PHARMACEUTICAL RESEARCH, 1991, 8 (12) : 1453 - 1460
  • [3] THE INFLUENCE OF PEPTIDE STRUCTURE ON TRANSPORT ACROSS CACO-2 CELLS .2. PEPTIDE-BOND MODIFICATION WHICH RESULTS IN IMPROVED PERMEABILITY
    CONRADI, RA
    HILGERS, AR
    HO, NFH
    BURTON, PS
    [J]. PHARMACEUTICAL RESEARCH, 1992, 9 (03) : 435 - 439
  • [4] DESIGN OF POTENT COMPETITIVE INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME - CARBOXYALKANOYL AND MERCAPTOALKANOYL AMINO-ACIDS
    CUSHMAN, DW
    CHEUNG, HS
    SABO, EF
    ONDETTI, MA
    [J]. BIOCHEMISTRY, 1977, 16 (25) : 5484 - 5491
  • [5] X-RAY ANALYSES OF PEPTIDE-INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS
    DHANARAJ, V
    DEALWIS, CG
    FRAZAO, C
    BADASSO, M
    SIBANDA, BL
    TICKLE, IJ
    COOPER, JB
    DRIESSEN, HPC
    NEWMAN, M
    AGUILAR, C
    WOOD, SP
    BLUNDELL, TL
    HOBART, PM
    GEOGHEGAN, KF
    AMMIRATI, MJ
    DANLEY, DE
    OCONNOR, BA
    HOOVER, DJ
    [J]. NATURE, 1992, 357 (6378) : 466 - 472
  • [6] MOLECULAR FORCES GOVERNING NON-ELECTROLYTE PERMEATION THROUGH CELL MEMBRANES
    DIAMOND, JM
    WRIGHT, EM
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1969, 172 (1028): : 273 - +
  • [7] HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES
    FOUNDLING, SI
    COOPER, J
    WATSON, FE
    CLEASBY, A
    PEARL, LH
    SIBANDA, BL
    HEMMINGS, A
    WOOD, SP
    BLUNDELL, TL
    VALLER, MJ
    NOREY, CG
    KAY, J
    BOGER, J
    DUNN, BM
    LECKIE, BJ
    JONES, DM
    ATRASH, B
    HALLETT, A
    SZELKE, M
    [J]. NATURE, 1987, 327 (6120) : 349 - 352
  • [8] 3-TETRAHYDROFURAN AND PYRAN URETHANES AS HIGH-AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS
    GHOSH, AK
    THOMPSON, WJ
    MCKEE, SP
    DUONG, TT
    LYLE, TA
    CHEN, JC
    DARKE, PL
    ZUGAY, JA
    EMINI, EA
    SCHLEIF, WA
    HUFF, JR
    ANDERSON, PS
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (02) : 292 - 294
  • [9] AFFINITY PURIFICATION OF THE HIV-1 PROTEASE
    HEIMBACH, JC
    GARSKY, VM
    MICHELSON, SR
    DIXON, RAF
    SIGAL, IS
    DARKE, PL
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (03) : 955 - 960
  • [10] THE 1ST DESIGN AND SYNTHESIS OF A STEROIDAL PEPTIDOMIMETIC - THE POTENTIAL VALUE OF PEPTIDOMIMETICS IN ELUCIDATING THE BIOACTIVE CONFORMATION OF PEPTIDE LIGANDS
    HIRSCHMANN, R
    SPRENGELER, PA
    KAWASAKI, T
    LEAHY, JW
    SHAKESPEARE, WC
    SMITH, AB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (24) : 9699 - 9701