THE MECHANISM OF ACTION OF CHLORHEXIDINE

被引：68

作者：

KUYYAKANOND, T ^{[1
]}

QUESNEL, LB ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CELL & STRUCT BIOL,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

FEMS MICROBIOLOGY LETTERS | 1992年 / 100卷 / 1-3期

关键词：

CARBOHYDRATE TRANSPORT; ATPASE INHIBITION; ATP HYDROLYSIS; PROTON CONDUCTION; MEMBRANE DISRUPTION; CHLORHEXIDINE EFFECT;

D O I：

10.1016/0378-1097(92)90211-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chlorhexidine did not inhibit ATPase in intact cells of Escherichia coli K12 W1317i-, even at bactericidal concentrations, and ATP hydrolysis was greatest at the highest concentration (40 mg/1), even though no net uptake of substrate occurred. Like dinitrophenol and tribrominated salicylanilide, polymyxin and chlorhexidine collapsed the membrane potential at inhibitory concentrations. Membrane disruption, and not ATPase inactivatiion, is considered the lethal event in chlorhexidine action.

引用

页码：211 / 215

页数：5

共 11 条

[1] SYNERGISM BETWEEN CHLORHEXIDINE AND POLYMYXINS AGAINST PSEUDOMONAS-AERUGINOSA [J].

ALNAJJAR, AR ;

QUESNEL, LB .

JOURNAL OF APPLIED BACTERIOLOGY, 1979, 47 (03) :469-476

[2] EFFECT OF PHENOLIC ANTIBACTERIAL AGENT FENTICHLOR ON ENERGY COUPLING IN STAPHYLOCOCCUS-AUREUS [J].

BLOOMFIELD, SF .

JOURNAL OF APPLIED BACTERIOLOGY, 1974, 37 (01) :117-131

[3] INHIBITION OF PROVIDENCIA-STUARTII CELL-ENVELOPE ENZYMES BY CHLORHEXIDINE [J].

CHOPRA, I ;

JOHNSON, SC ;

BENNETT, PM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1987, 19 (06) :743-751

[4]

GALE EF, 1981, MOL BASIS ANTIBIOTIC, P243

[5] DIO-9 AND CHLORHEXIDINE - INHIBITORS OF MEMBRANE-BOUND ATPASE AND OF CATION TRANSPORT IN STREPTOCOCCUS FAECALIS [J].

HAROLD, FM ;

BAARDA, JR ;

BARON, C ;

ABRAMS, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 183 (01) :129-&

[6] EFFECTS OF CHLORHEXIDINE DIACETATE ON CANDIDA-ALBICANS, C-GLABRATA AND SACCHAROMYCES-CEREVISIAE [J].

HIOM, SJ ;

FURR, JR ;

RUSSELL, AD ;

DICKINSON, JR .

JOURNAL OF APPLIED BACTERIOLOGY, 1992, 72 (04) :335-340

[7] SOME ASPECTS OF MODE OF ACTION OF CHLORHEXIDINE [J].

HUGO, WB ;

LONGWORTH, AR .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1964, 16 (10) :655-&

[8]

HUGO WB, 1992, PRINCIPLES PRACTICE, P195

[9]

KUYYAKANOND T, 1980, THESIS U MANCHESTER

[10] ENERGY COUPLING IN TRANSPORT OF BETA-GALACTOSIDES BY ESCHERICHIA COLI - EFFECT OF PROTON CONDUCTORS [J].

PAVLASOVA, E ;

HAROLD, FM .

JOURNAL OF BACTERIOLOGY, 1969, 98 (01) :198-+

← 1 2 →