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REGULATION OF TRANSLATION AND CELL-GROWTH BY EIF-4E

被引：112
作者：
SONENBERG, N [1 ]
机构：
[1] MCGILL UNIV, MCGILL CANC CTR, MONTREAL H3G 1Y6, PQ, CANADA
来源：
BIOCHIMIE | 1994年 / 76卷 / 09期
基金：
英国医学研究理事会;
关键词：
TRANSLATION; EIF-4E; PROTEIN SYNTHESIS; MESSENGER-RNA;
D O I：
10.1016/0300-9084(94)90185-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.
引用
收藏
页码：839 / 846
页数：8
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