REGULATION OF TRANSLATION AND CELL-GROWTH BY EIF-4E

被引：112

作者：

SONENBERG, N ^{[1
]}

机构：

[1] MCGILL UNIV, MCGILL CANC CTR, MONTREAL H3G 1Y6, PQ, CANADA

来源：

BIOCHIMIE | 1994年 / 76卷 / 09期

基金：

英国医学研究理事会;

关键词：

TRANSLATION; EIF-4E; PROTEIN SYNTHESIS; MESSENGER-RNA;

D O I：

10.1016/0300-9084(94)90185-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.

引用

页码：839 / 846

页数：8

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