COMBINED DIRECTED ORTHO-METALATION CROSS-COUPLING STRATEGIES - DESIGN FOR NATURAL PRODUCT SYNTHESIS

被引：17

作者：

SNIECKUS, V

机构：

[1] Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Waterloo, Waterloo

来源：

PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 10-11期

关键词：

D O I：

10.1351/pac199466102155

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent efforts in our laboratories have established connections between the Directed ortho Metalation (DoM) (Scheme 1) and transition metal catalyzed cross coupling (Scheme 2) strategies. The combination of these with the Remote Metalation (Scheme 4) tactic has led to the evolution of powerful new methods for aromatic synthesis. The application of these concepts, singularly or combined, for the construction of alkaloids (Scheme 6), fluorenone natural products (Schemes 7, and 8), naphthobenzopyranones (Schemes 9 and 10), and naturally-occurring phenanthrenes is given as illustration of the new synthetic aromatic chemistry.

引用

页码：2155 / 2158

页数：4

共 16 条

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