PRADIMICIN-FS AND PRADIMICIN-FB, NEW PRADIMICIN ANALOGS - DIRECTED PRODUCTION, STRUCTURES AND BIOLOGICAL-ACTIVITIES

被引：20

作者：

SAITOH, K ^{[1
]}

SUZUKI, K ^{[1
]}

HIRANO, M ^{[1
]}

FURUMAI, T ^{[1
]}

OKI, T ^{[1
]}

机构：

[1] CARE OF OKUMURA J,BRISTOL MYERS SQUIBB RES INST,2-9-3 SHIMO-MEGURO,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 03期

关键词：

D O I：

10.7164/antibiotics.46.398

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.

引用

页码：398 / 405

页数：8

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