QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS .1. PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY

被引：33

作者：

TSUNAKAWA, M

TENMYO, O

TOMITA, K

NARUSE, N

KOTAKE, C

MIYAKI, T

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 02期

关键词：

D O I：

10.7164/antibiotics.45.180

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.

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页码：180 / 188

页数：9

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