GEOMETRY OF INTERPLANAR RESIDUE CONTACTS IN PROTEIN STRUCTURES

被引:91
作者
BROCCHIERI, L
KARLIN, S
机构
[1] Department of Mathematics, Stanford University, Stanford
关键词
D O I
10.1073/pnas.91.20.9297
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The relative spatial disposition of interacting side-chain planar groups (aromatic, guanidinium, amide, carboxyl, imidazole) is analyzed for 186 non-homologous well-resolved protein structures. The dihedral angle of amide or carboxyl planar groups with other planar groups accords with a random distribution of planes. By contrast, the dihedral angle of the planes between close aromatic rings or of the histidine ring interacting with aromatic residues is significantly nonrandom, showing an approximately uniform distribution. Our results indicate that edge-to edge and edge-to-center spatial dispositions of residue planar sections are prevalent, while complete stacking configurations are uncommon. The hypothesis that electrostatic forces are a major determinant of the geometry of interactions between side-chain planar groups is discussed.
引用
收藏
页码:9297 / 9301
页数:5
相关论文
共 24 条
  • [1] THE (I, I+4) PHE-HIS INTERACTION STUDIED IN AN ALANINE-BASED ALPHA-HELIX
    ARMSTRONG, KM
    FAIRMAN, R
    BALDWIN, RL
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1993, 230 (01) : 284 - 291
  • [2] AROMATIC INTERACTIONS
    BLUNDELL, T
    SINGH, J
    THORNTON, J
    BURLEY, SK
    PETSKO, GA
    [J]. SCIENCE, 1986, 234 (4779) : 1005 - 1005
  • [3] STUDIES OF SYNTHETIC HELICAL PEPTIDES USING CIRCULAR-DICHROISM AND NUCLEAR-MAGNETIC-RESONANCE
    BRADLEY, EK
    THOMASON, JF
    COHEN, FE
    KOSEN, PA
    KUNTZ, ID
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (04) : 607 - 622
  • [4] BURLEY SK, 1988, ADV PROTEIN CHEM, V39, P125
  • [5] AROMATIC-AROMATIC INTERACTION - A MECHANISM OF PROTEIN-STRUCTURE STABILIZATION
    BURLEY, SK
    PETSKO, GA
    [J]. SCIENCE, 1985, 229 (4708) : 23 - 28
  • [6] AMINO-AROMATIC INTERACTIONS IN PROTEINS
    BURLEY, SK
    PETSKO, GA
    [J]. FEBS LETTERS, 1986, 203 (02) : 139 - 143
  • [7] NEW MUTANTS TO EXPLORE NICOTINIC RECEPTOR FUNCTIONS
    CHANGEUX, JP
    DEVILLERSTHIERY, A
    GALZI, JL
    BERTRAND, D
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (08) : 299 - 301
  • [8] ACETYLCHOLINE BINDING BY A SYNTHETIC RECEPTOR - IMPLICATIONS FOR BIOLOGICAL RECOGNITION
    DOUGHERTY, DA
    STAUFFER, DA
    [J]. SCIENCE, 1990, 250 (4987) : 1558 - 1560
  • [9] PLANAR STACKING INTERACTIONS OF ARGININE AND AROMATIC SIDE-CHAINS IN PROTEINS
    FLOCCO, MM
    MOWBRAY, SL
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 235 (02) : 709 - 717
  • [10] PI-PI-INTERACTIONS - THE GEOMETRY AND ENERGETICS OF PHENYLALANINE PHENYLALANINE INTERACTIONS IN PROTEINS
    HUNTER, CA
    SINGH, J
    THORNTON, JM
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1991, 218 (04) : 837 - 846