BETA-GALACTOSIDASE DEFICIENT-TYPE MUCOLIPODOSIS - COMPLEMENTATION STUDY OF NEURAMINIDASE IN SOMATIC-CELL HYBRIDS

By cell fusion with polyethylene glycol (PEG) a remarkable increase of neuraminidase activity was observed in the fused cells between ML-II and other two neuraminidase deficient disorders, ML-Gal (mucolipidosis, galactosidase deficient type) and ML-I (mucolipidosis I). No complementation was found in the combination of ML-I and ML-Gal. This result suggests that ML-I and ML-Gal may be allelic mutations and belong to the same genetic disorder as a primary neuraminidase deficiency. © 1979.