DETERMINATION OF ZOPICLONE IN PLASMA USING COLUMN LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET DETECTION

被引：20

作者：

ROYERMORROT, MJ ^{[2
]}

RAMBOURG, M

JACOB, I

BAUER, P

ROYER, RJ

机构：

[1] HOP CENT NANCY,CTR ANTIPOISONS,DEPT URGENCE & REANIMAT,F-54035 NANCY,FRANCE

[2] HOP CENT NANCY,SERV PHARMACOL CLIN & TOXICOL,F-54035 NANCY,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 581卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80286-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A reversed-phase liquid chromatographic method with ultraviolet detection for the determination of zopiclone in plasma is described. It is rapid, sensitive, reproducible and linear over a wide range. The method was used to study plasma zopiclone concentrations in a case of acute intoxication after oral ingestion of 300 mg of the drug. The plasma level was 1600 ng/ml 4.5 h after the dose and the elimination half-life was 3.5 h.

引用

页码：297 / 299

页数：3

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