THE ROLE OF IL-12 IN THE INDUCTION OF ORGAN-SPECIFIC AUTOIMMUNE-DISEASES

被引：238

作者：

TREMBLEAU, S

GERMANN, T

GATELY, MK

ADORINI, L

机构：

[1] INST IMMUNOL,D-55131 MAINZ,GERMANY

[2] HOFFMANN LA ROCHE INC,DEPT INFLAMMAT AUTOIMMUNE DIS,NUTLEY,NJ 07110

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 08期

关键词：

D O I：

10.1016/0167-5699(95)80006-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept that T cells are subdivided into T helper 1 (Th1) and Th2 subsets was recently extended to suggest that Th1 cells contribute to the pathogenesis of several organ-specific autoimmune diseases, whereas Th2 cells inhibit disease development. Here, Sylvie Trembleau and colleagues examine the role of interleukin 12 (IL-12), a Key cytokine guiding the development of Th1 cells, in the induction of autoimmune diseases, and discuss potential immunointervention strategies based on administration of IL-12 antagonists.

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页码：383 / 386

页数：4

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