HUMAN STRIATUM - THE DISTRIBUTION OF NEUROFIBRILLARY TANGLES IN ALZHEIMERS-DISEASE

被引：43

作者：

SELDEN, N

MESULAM, MM

GEULA, C

机构：

[1] HARVARD UNIV,SCH MED,DEPT NEUROL,BULLARD & DENNY BROWN LABS,BOSTON,MA 02215

[2] BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215

来源：

BRAIN RESEARCH | 1994年 / 648卷 / 02期

关键词：

ALZHEIMERS DISEASE; STRIATUM; TANGLE; PLAQUE; LIMBIC SYSTEM; VENTRAL STRIATUM;

D O I：

10.1016/0006-8993(94)91136-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayed significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogeneously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.

引用

页码：327 / 331

页数：5

共 23 条

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