THE ROLE OF EPSTEIN-BARR-VIRUS SUBTYPES IN HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED LYMPHOMA

被引:12
作者
BOYLE, MJ [1 ]
SCULLEY, TB [1 ]
PENNY, R [1 ]
SEWELL, WA [1 ]
TSCHUCHNIGG, M [1 ]
BERGER, MF [1 ]
COOPER, DA [1 ]
机构
[1] ST VINCENTS HOSP,CTR IMMUNOL,SYDNEY,NSW 2010,AUSTRALIA
关键词
HIV-ASSOCIATED LYMPHOMA; EBV; EBV SUBTYPES; HUMAN IMMUNODEFICIENCY VIRUS;
D O I
10.3109/10428199309147352
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
High grade B cell non-Hodgkin's lymphoma (NHL) is an increasingly important problem in individuals infected with the human immunodeficiency virus (HIV). Fifty percent of these tumours harbour the Epstein-Barr virus (EBV) and there is an equal frequency of EBV A and B-subtypes in the tumours. This contrasts with the recent report that only A-type EBV is associated with Hodgkin's disease. Such studies are challenging the traditional models of EBV-associated lymphomagenesis and showing the way for further studies in this field. This article reviews the studies of EBV subtypes in HIV-associated NHL and uses this new knowledge to discuss the role of EBV in lymphomagenesis.
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页码:17 / 23
页数:7
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