SYNTHESIS OF NOVEL CYCLIC HYDROXAMIC ACIDS

被引：11

作者：

CHITTARI, P ^{[1
]}

THOMAS, A ^{[1
]}

RAJAPPA, S ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM SYNTH,POONA 411008,MAHARASHTRA,INDIA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)73101-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nitroacetyl (S)-proline esters (1,3,5) are reduced by zinc-NH4Cl to the hydroxylamine stage and cyclized to provide the novel chiral bicyclic hydroxamic acids (2,4,6). Michael addition of allyl acrylate on nitroacetic acid derivatives followed by Pd(O) catalyzed intramolecular allyl transfer and subsequent reduction of the nitro group yielded a novel class of cyclic hydroxamic acids related to pyroglutamic acid.

引用

页码：3793 / 3796

页数：4

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