ISOLATION AND BIOSYNTHESIS OF 3-ALPHA-HYDROXY-3,5-DIHYDROMONACOLIN-L

被引：25

作者：

NAKAMURA, T

KOMAGATA, D

MURAKAWA, S

SAKAI, K

ENDO, A

机构：

[1] Department of Applied Biological Sciences, Tokyo Noko University, Fuchu-Shi

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 12期

关键词：

D O I：

10.7164/antibiotics.43.1597

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

3-alpha-Hydroxy-3,5-dihydromonacolin L acid (acid form), a new compound related to monacolin K (mevinolin), was isolated from the culture broth of a strain of Monascus ruber. The structure of the compound was determined by a combination of physical techniques. 4a,5-Dihydromonacolin L was converted to 3-alpha-hydroxy-3,5-dihydromonacolin L by a cell-free extract of M. ruber in the presence of molecular oxygen. The results demonstrate that the former is the direct precursor in the biosynthesis of the latter.

引用

页码：1597 / 1600

页数：4

共 11 条

[1]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

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