SYNTHESIS OF ANALOGS OF SQUALENE AS POTENTIAL ANTIFUNGAL AGENTS

被引：6

作者：

DURIATI, A

JUNG, M

MANN, J

SMITH, GP

机构：

[1] UNIV READING,DEPT CHEM,WHITEKNIGHTS,READING RG6 2AD,ENGLAND

[2] DOW ELANCO,LETCOMBE LAB,LETCOMBE REGIS,WANTAGE OX12 9JT,OXON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 24期

关键词：

D O I：

10.1039/p19930003073

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Squalene was selectively degraded to tris-norsqualene, and this was converted into 1 -fluoro, 1,1 -difluoro, and 2-trimethylsilylmethyl analogues of squalene, and also into 2-cyanonorsqualene. These compounds were designed as potential inhibitors of fungal squalene epoxidase/epoxysqualene cyclase, but biological evaluation using five fungal pathogens revealed that none exhibited more than modest antifungal activity.

引用

页码：3073 / 3076

页数：4

共 13 条

[1] 26-HYDROXYSQUALENE AND DERIVATIVES - SUBSTRATES AND INHIBITORS FOR SQUALENE EPOXIDASE [J].