NEUROTRANSMITTER-GATED ION CHANNELS AS UNCONVENTIONAL ALLOSTERIC PROTEINS

被引：191

作者：

GALZI, JL

CHANGEUX, JP

机构：

[1] Institut Pasteur, Neurobiologie Moléculaire, URA CNRS D1284, 75015 Paris

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(94)90218-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biochemical, mutagenesis and electron microscopy investigations of neurotransmitter receptors linked with ion channels result in a map of the neurotransmitter binding site and the ion channel at the amino acid level. The data are consistent with the view that these quasi-symmetrical hetero-oligomers are allosteric proteins, yet with distinctive features associated with their transmembrane disposition.

引用

页码：554 / 565

页数：12

共 99 条

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