METHOTREXATE ANALOGS .26. INHIBITION OF DIHYDROFOLATE-REDUCTASE AND FOLYLPOLYGLUTAMATE SYNTHETASE-ACTIVITY AND INVITRO TUMOR-CELL GROWTH BY METHOTREXATE AND AMINOPTERIN ANALOGS CONTAINING A BASIC-AMINO-ACID SIDE-CHAIN

被引：58

作者：

ROSOWSKY, A

FREISHEIM, JH

MORAN, RG

SOLAN, VC

BADER, H

WRIGHT, JE

RADIKESMITH, M

机构：

[1] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115

[2] MED COLL OHIO,DEPT BIOCHEM,TOLEDO,OH 43699

[3] CHILDRENS HOSP,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1986年 / 29卷 / 05期

关键词：

D O I：

10.1021/jm00155a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：655 / 660

页数：6

共 38 条

[1] QUANTITATIVE STUDIES OF THE AVIDITY OF NATURALLY OCCURRING SUBSTANCES FOR TRACE METALS .2. AMINO-ACIDS HAVING 3 IONIZING GROUPS [J].

ALBERT, A .

BIOCHEMICAL JOURNAL, 1952, 50 (05) :690-698

[2] POLYPEPTIDES .V. USE OF T-BUTYL 2,4,5-TRICHLOROPHENYL CARBONATE IN SYNTHESIS OF N-T-BUTOXYCARBONYL AMINO-ACIDS AND THEIR 2,4,5-TRICHLOROPHENYL ESTERS [J].

BROADBENT, W ;

MORLEY, JS ;

STONE, BE .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (24) :2632-+

[3]

CICHOWICZ DJ, 1985, 2ND P WORKSH FOL ANT, P7

[4]

CLELAND WW, 1967, ADV ENZYMOL RAMB, V29, P1

[5]

COHEN M, 1978, CANCER RES, V38, P2866

[6]

COWARD JK, 1979, DEV BIOCHEM, V6, P13

[7]

FORSCH RA, 1985, P AM ASS CANCER RES, V26, P22

[8]

FREISHEIM JH, 1983, PTERIDINE FOLIC ACID, P223

[9] GAMMA-FLUOROMETHOTREXATE - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A POTENT INHIBITOR OF DIHYDROFOLATE-REDUCTASE WITH GREATLY DIMINISHED ABILITY TO FORM POLY-GAMMA-GLUTAMATES [J].

GALIVAN, J ;

INGLESE, J ;

MCGUIRE, JJ ;

NIMEC, Z ;

COWARD, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :2598-2602

[10] SYNTHESIS AND CHARACTERIZATION OF A FLUORESCENT ANALOG OF METHOTREXATE [J].

KUMAR, AA ;

FREISHEIM, JH ;

KEMPTON, RJ ;

ANSTEAD, GM ;

BLACK, AM ;

JUDGE, L .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (01) :111-113

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