METHOTREXATE ANALOGS .26. INHIBITION OF DIHYDROFOLATE-REDUCTASE AND FOLYLPOLYGLUTAMATE SYNTHETASE-ACTIVITY AND INVITRO TUMOR-CELL GROWTH BY METHOTREXATE AND AMINOPTERIN ANALOGS CONTAINING A BASIC-AMINO-ACID SIDE-CHAIN

被引:58
作者
ROSOWSKY, A
FREISHEIM, JH
MORAN, RG
SOLAN, VC
BADER, H
WRIGHT, JE
RADIKESMITH, M
机构
[1] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115
[2] MED COLL OHIO,DEPT BIOCHEM,TOLEDO,OH 43699
[3] CHILDRENS HOSP,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027
关键词
D O I
10.1021/jm00155a012
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:655 / 660
页数:6
相关论文
共 38 条
[11]   FLUORESCENT ANALOGS OF METHOTREXATE - CHARACTERIZATION AND INTERACTION WITH DIHYDROFOLATE-REDUCTASE [J].
KUMAR, AA ;
KEMPTON, RJ ;
ANSTEAD, GM ;
FREISHEIM, JH .
BIOCHEMISTRY, 1983, 22 (02) :390-395
[12]   CHARACTERIZATION OF THE METHOTREXATE TRANSPORT DEFECT IN A RESISTANT L1210-LYMPHOMA CELL-LINE [J].
MCCORMICK, JI ;
SUSTEN, SS ;
FREISHEIM, JH .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1981, 212 (01) :311-318
[13]  
MCGUIRE JJ, 1985, J BIOL CHEM, V260, P6747
[14]   MEASUREMENT OF FOLYLPOLYGLUTAMATE SYNTHETASE IN MAMMALIAN-TISSUES [J].
MORAN, RG ;
COLMAN, PD .
ANALYTICAL BIOCHEMISTRY, 1984, 140 (02) :326-342
[15]  
MORAN RG, 1985, MOL PHARMACOL, V27, P156
[16]  
MORAN RG, 1983, ADV EXP MED BIOL, V163, P327
[17]   A MECHANISM FOR THE ADDITION OF MULTIPLE MOLES OF GLUTAMATE BY FOLYLPOLYGLUTAMATE SYNTHETASE [J].
MORAN, RG ;
COLMAN, PD ;
FORSCH, RA ;
ROSOWSKY, A .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (10) :1263-1267
[18]  
MORAN RG, 1985, 2ND P WORKSH FOL ANT, P51
[19]   FOLATE ANALOGS .17. SYNTHESIS OF PTEROIC ACID AND 4-AMINO-4-DEOXYPTEROIC ACID [J].
NAIR, MG ;
ADAPA, SR ;
BRIDGES, TW .
JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (15) :3152-3155
[20]  
PARRY D, 1975, EUR J MED CHEM, V10, P147