ENANTIOMERIC RESOLUTION OF CHIRAL IMIDAZOLE DERIVATIVES USING CAPILLARY ELECTROPHORESIS WITH CYCLODEXTRIN-TYPE BUFFER MODIFIERS

Enantiomeric resolutions of some chiral pharmaceuticals containing the imidazole (1,3-diazole) moiety were carried out using capillary electrophoresis. Various native cyclodextrins (alpha-, beta- and gamma-cyclodextrin) and derivatized cydodextrins (hydroxypropyl-, and sulfobutyl ether-beta-cyclodextrin) were used as chiral buffer modifiers. The effects of the cavity size, the structure and the charge of the selectors on the chiral recognition ability were evaluated. The influence of the type and concentration of the organic modifier on the separation of miconazole enantiomers and the pH of the run buffer on the separation of enilconazole enantiomers was also studied.