GENERATION AND USE OF A ZINC DERIVATIVE OF A FUNCTIONALIZED 1,3-OXAZOLE - SOLUTION OF THE VIRGINIAMYCIN MADUMYCIN OXAZOLE PROBLEM

被引：34

作者：

GANGLOFF, AR

AKERMARK, B

HELQUIST, P

机构：

[1] ROYAL INST TECHNOL,DEPT ORGAN CHEM,S-10044 STOCKHOLM 70,SWEDEN

[2] UNIV NOTRE DAME,DEPT CHEM & BIOCHEM,NOTRE DAME,IN 46556

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 18期

关键词：

D O I：

10.1021/jo00044a009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(Bromomethyl)-4-carbethoxy-1,3-oxazole reacts with Zn dust to give a new heteroaromatic "benzylic" organozinc derivative which undergoes nucleophilic addition to a variety of aldehydes and ketones; application to the synthesis of virginiamycin and other streptogramin antibiotics is envisioned.

引用

页码：4797 / 4799

页数：3

共 31 条

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