IRREVERSIBLE AND REVERSIBLE BLOCKADE OF IMR32 CALCIUM-CHANNEL CURRENTS BY SYNTHETIC MVIIA AND IODINATED MVIIC OMEGA-CONOPEPTIDES

被引：18

作者：

FOX, JA

机构：

[1] Axon Instruments Inc., Foster City, 94404, CA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1995年 / 429卷 / 06期

关键词：

CALCIUM CHANNEL; OMEGA-CONOTOXIN; IMR32;

D O I：

10.1007/BF00374813

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The actions of two w-conopeptides on high-voltage-activated calcium channel currents in differentiated human neuroblastoma IMR32 cells were investigated, Similar to the previously reported action of w-conopeptide GVIA, w-conopeptide MVIIA irreversibly blocks IMR32 HVA calcium channel currents at low concentrations, Unlike GVIA action, however, novel w-conopeptide SNX-260 (iodinated MVIIC) reversibly blocks these currents, also at low concentrations, with an IC50 near 50 nM. Different w-conopeptides may be potent blockers of HVA calcium channel currents yet act either reversibly or irreversibly in a single cell.

引用

收藏

页码：873 / 875

页数：3

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