PREPARATION OF HIGHLY ENANTIOPURE PYRIDYLETHANOLS BY BAKERS-YEAST REDUCTIONS

被引:15
作者
BAILEY, D
OHAGAN, D
DYER, U
LAMONT, RB
机构
[1] UNIV DURHAM,DEPT CHEM,SCI LABS,S RD,DURHAM DH1 3LE,ENGLAND
[2] GLAXO GRP RES LTD,WARE SG12 ODP,HERTS,ENGLAND
[3] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND
关键词
D O I
10.1016/S0957-4166(00)80237-2
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Bakers' yeast is used to prepare 3a, 4a and 5a in high enantiomeric purity by addition of allyl alcohol to the reaction. The double reduction of 2,6-diacetylpyridine 2 with bakers' yeast leads to 5a with essentially complete enantiomeric purity predicted to be 99.97%ee.
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页码:1255 / 1258
页数:4
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