IDENTIFICATION OF THE FELINE HERPESVIRUS TYPE-1 (FHV-1) GENES ENCODING GLYCOPROTEIN-G, GLYCOPROTEIN-D, GLYCOPROTEIN-I AND GLYCOPROTEIN-E - EXPRESSION OF FHV-1 GLYCOPROTEIN-D IN VACCINIA AND RACCOON POXVIRUSES

被引:42
作者
SPATZ, SJ
ROTA, PA
MAES, RK
机构
[1] MICHIGAN STATE UNIV, DEPT MICROBIOL, E LANSING, MI 48824 USA
[2] MICHIGAN STATE UNIV, ANIM HLTH DIAGNOST LAB, E LANSING, MI 48824 USA
[3] CTR DIS CONTROL & PREVENT, DIV VIRAL & RICKETTSIAL DIS, ATLANTA, GA 30333 USA
关键词
D O I
10.1099/0022-1317-75-6-1235
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The genome of feline herpesvirus type 1 (FHV-1), the major cause of viral upper respiratory disease in cats, contains several genes encoding homologues of herpes simplex virus type 1 (HSV-1) glycoproteins. Restriction mapping studies have indicated that the group D genome of FHV-1 contains a unique short region that is 9.0 kb long. The nucleotide sequence of a 6.2 kb portion of this region was determined. Analyses of this sequence have identified five open reading frames capable of encoding homologues to HSV-1 protein kinase and glycoproteins gG, gD, gI and gE. Since go of FHV-1 is most likely an immunologically important polypeptide, vaccinia and raccoon poxvirus recombinants expressing this glycoprotein were generated. In an indirect fluorescent antibody test these recombinants reacted strongly with a rabbit anti-FHV-1 serum. High titres of virus-neutralizing antibodies were also generated in rabbits inoculated with the vaccinia virus recombinant. A 53K viral polypeptide (gD) was detected with this antiserum on Western blots containing polypeptides from potassium tartrate-purified virions.
引用
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页码:1235 / 1244
页数:10
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