SYNTHESIS OF N-(2-DEOXY-BETA-D-RIBOSYL) 4-THIOMETHYLINDOLE - A PURINE SURROGATE FOR INCORPORATION INTO OLIGONUCLEOTIDES

被引：11

作者：

COLEMAN, RS

DONG, Y

ARTHUR, JC

机构：

[1] Department of Chemistry, Biochemistry University of South Carolina, Columbia

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)91816-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient, high-yielding syntheses of S-acetyl-N-(2-deoxy-beta-D-ribosyl) 4 thiomethylindole (9) and the corresponding 5'-O-trityl-3'-0-phosphoramidite ester 11 are reported, suitable for direct incorporation into oligodeoxynucleotides by standard solid-phase synthesis techniques.

引用

页码：6867 / 6870

页数：4

共 42 条

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