IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS-VACCINE COMPOSED OF GENETICALLY INACTIVATED PERTUSSIS TOXIN COMBINED WITH FILAMENTOUS HEMAGGLUTININ AND PERTACTIN IN INFANTS AND CHILDREN

被引：20

作者：

PODDA, A

DELUCA, EC

TITONE, L

CASADEI, AM

CASCIO, A

BARTALINI, M

VOLPINI, G

PEPPOLONI, S

MARSILI, I

NENCIONI, L

RAPPUOLI, R

机构：

[1] BIOCINE SCLAVO RES & DEV VACCINES, VIA FIORENTINA 1, I-53100 SIENA, ITALY

[2] UNIV ROMA LA SAPIENZA, IST PUERICULTURA, I-00185 ROME, ITALY

[3] UNIV PALERMO, MALATTIE INFETT CLIN, I-90134 PALERMO, ITALY

来源：

JOURNAL OF PEDIATRICS | 1993年 / 123卷 / 01期

关键词：

D O I：

10.1016/S0022-3476(05)81543-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We studied the immunogenicity of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin (PT-9K/129G), filamentous haemagglutinin, and a 69-kilodalton protein, pertactin, in 30 children aged 12 to 24 months and in 80 infants aged 2 to 4 months. A significant increase of the neutralizing titer and of the titers against pertussis toxin, filamentous hemagglutinin, and pertactin, as determined by enzyme-linked immunosorbent assay, was achieved after three doses of vaccine in all the children; a significant increase of these antibody titers was obtained in 100%, 96.1%, 93.5%, and 98.7% of the infants, respectively.

引用

页码：81 / 84

页数：4

共 9 条

[1]

EDWARDS KM, 1992, P AM PEDIATRIC SOC S

[2]

ENGLUND JA, 1991, 31ST INT C ANT AG CH

[3] INDUCTION OF A NOVEL MORPHOLOGICAL RESPONSE IN CHINESE-HAMSTER OVARY CELLS BY PERTUSSIS TOXIN [J].