CONSTITUTIVE PRODUCTION OF ANGIOTENSIN CONVERTING ENZYME FROM RHEUMATOID NODULE CELLS UNDER SERUM FREE CONDITIONS

被引：18

作者：

GOTO, M

SASANO, M

FUZISAWA, M

OKABE, T

NISHIZAWA, K

机构：

[1] TOKYO WOMENS MED COLL,INST RHEUMATOL,TOKYO 162,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,TOKYO 113,JAPAN

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 06期

关键词：

D O I：

10.1136/ard.51.6.741

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin converting enzyme was assayed in serum free culture supernatants from unstimulated rheumatoid nodule cells. Angiotensin converting enzyme was released spontaneously and the angiotensin converting enzyme derived from rheumatoid nodule cells was suppressed in a dose and time dependent manner by the protein synthesis inhibitor cycloheximide. These data suggest the constitutive de novo synthesis of angiotensin converting enzyme by rheumatoid nodule cells.

引用

页码：741 / 742

页数：2