THE CELL-ADHESION MOLECULE L1 HAS A SPECIFIC ROLE IN NEURAL CELL-MIGRATION

被引：29

作者：

ASOU, H

MIURA, M

KOBAYASHI, M

UYEMURA, K

机构：

[1] Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160, Shinanomachi

来源：

NEUROREPORT | 1992年 / 3卷 / 06期

关键词：

CELL MIGRATION; L1; MOLECULE; REAGGREGATED CULTURES;

D O I：

10.1097/00001756-199206000-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

L1-TRANSFECTED L cells show a markedly enhanced ability for neuronal cell binding and promotion of neuron migration compared with control L cells. Further, when purified L1 was used as a culture substrate for neurons, it was found to promote neuronal adhesion and enhance the speed of migration of cerebellar neurons from reaggregated cultures, indicating that it is involved in a determinant step of neural cell migration.

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页码：481 / 484

页数：4

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