THE EXPRESSION OF A SPECIFIC 2-DEOXYGLUCOSE-6P PHOSPHATASE PREVENTS CATABOLITE REPRESSION MEDIATED BY 2-DEOXYGLUCOSE IN YEAST

被引：25

作者：

RANDEZGIL, F ^{[1
]}

PRIETO, JA ^{[1
]}

SANZ, P ^{[1
]}

机构：

[1] UNIV VALENCIA, CSIC, INST AGROQUIM & TECNOL ALIMENTOS, DEPT BIOTECHNOL, E-4610 BURJASSOT, SPAIN

来源：

CURRENT GENETICS | 1995年 / 28卷 / 02期

关键词：

2-DEOXYGLUCOSE; 2-DEOXYGLUCOSE 6P PHOSPHATASE; CATABOLITE REPRESSION; SACCHAROMYCES CEREVISIAE;

D O I：

10.1007/BF00315774

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

2-deoxyglucose (2-DOG), a non-metabolize analogue of glucose, is taken up by yeast using the same transporter(s) as glucose and is phosphorylated by hexokinases producing 2-deoxyglucose-6-P. We found that in DOG(R) yeasts, 2-DOG was not able to trigger glucose repression, even at concentrations of 0.5%. This result suggests that the specific 2-DOG-6P phosphatase, the enzyme responsible for the DOG(R) phenotype, may be involved in inhibiting the process of catabolite repression mediated by 2-DOG.

引用

页码：101 / 107

页数：7

共 32 条

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