PREACTIVATION - A NOVEL ANTITUMOR AND ANTIVIRAL APPROACH

被引:16
作者
GULLIYA, KS [1 ]
CHANH, T [1 ]
NEWMAN, J [1 ]
PERVAIZ, S [1 ]
MATTHEWS, JL [1 ]
机构
[1] SW FDN BIOMED RES,SAN ANTONIO,TX 78284
关键词
D O I
10.1016/0277-5379(90)90072-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Merocyanine 540 was activated by exposure to 514 nm laser light. This preactivated merocyanine 540 was then mixed (in the dark) with tumour cells, normal cells and envelope viruses to assess its antiproliferative activity. This treatment resulted in 70-90% killing of tumour cells from different cell lines while 85% of normal human peripheral blood mononuclear cells survived the treatment. However, not all types of tumour cells were affected. Preactivated merocyanine 540 was also effective in virtually completely inactivating cell-free herpes simplex and human immunodeficiency viruses. Preactivated photoactive compounds can exert their toxic effects in the dark without further dependence on light and may have potential systemic use. © 1990.
引用
收藏
页码:551 / 553
页数:3
相关论文
共 17 条
  • [11] A MICROTITER CELL-CULTURE ASSAY FOR THE DETERMINATION OF ANTI-HUMAN IMMUNODEFICIENCY VIRUS NEUTRALIZING ANTIBODY-ACTIVITY
    ROBERTSON, GA
    KOSTEK, BM
    SCHLEIF, WA
    LEWIS, JA
    EMINI, EA
    [J]. JOURNAL OF VIROLOGICAL METHODS, 1988, 20 (03) : 195 - 202
  • [12] SCHMIDT NJ, 1979, DIAGNOSTIC PROCEDURE, P104
  • [13] SELECTIVE KILLING OF LEUKEMIC-CELLS BY MEROCYANINE 540-MEDIATED PHOTOSENSITIZATION
    SIEBER, F
    SPIVAK, JL
    SUTCLIFFE, AM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23): : 7584 - 7587
  • [14] SIEBER F, 1986, 1ST P WORKSH BON MAR, V2, P29
  • [15] SPIKES JD, 1985, PRIMARY PHOTOPROCESS, P1
  • [16] IMPROVED FLUOROCHROMATIC CYTOTOXIC TEST
    TAKASUGI, M
    [J]. TRANSPLANTATION, 1971, 12 (02) : 148 - &
  • [17] MEROCYANINE-540, A FLUORESCENT-PROBE SENSITIVE TO LIPID PACKING
    WILLIAMSON, P
    MATTOCKS, K
    SCHLEGEL, RA
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 732 (02) : 387 - 393