CLONING OF THE CDNA (DSC1) CODING FOR HUMAN TYPE-1 DESMOCOLLIN AND ITS ASSIGNMENT TO CHROMOSOME-18

被引:50
作者
KING, IA [1 ]
ARNEMANN, J [1 ]
SPURR, NK [1 ]
BUXTON, RS [1 ]
机构
[1] IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
关键词
D O I
10.1006/geno.1993.1453
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Desmosomes are adhesive epithelial junctions that contain two distinct classes of cadherin-related glycoproteins (desmogleins and desmocollins), both of which occur as several different isoforms whose expression is related to epithelial differentiation. We have now isolated cDNA clones encoding a human desmocollin that is expressed in the more differentiated layers of human epidermis. This isoform has 53% amino acid identity with the previously isolated human (type 3) desmocollin, which is expressed in the basal layers of the epidermis. However, the N- and C-termini of the mature proteins are more highly conserved. Using a panel of somatic cell hybrids, human type 1 desmocollin (gene DSC1) has been assigned to chromosome 18, the same location as the other desmocollin gene (DSC3) and the three desmoglein (DSG) genes already mapped. © 1993 Academic Press, Inc.
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页码:185 / 194
页数:10
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