HOW NATURE BUILDS THE PIGMENTS OF LIFE

被引：15

作者：

BATTERSBY, AR

机构：

[1] University Chemical Laboratory, Cambridge

来源：

PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 06期

关键词：

D O I：

10.1351/pac199365061113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vitamin B-12 (1) is the anti-pernicious anaemia vitamin and the coenzyme form is used by several different enzymes to bring about remarkable rearrangements in living systems. The lecture will focus on the question ''How is vitamin B-12 biosynthesised''. A very brief historical survey of what had been achieved earlier will be followed by a full account of the latest exciting advances. One take-home message is that any chemist aiming to solve the biosynthesis of a complex natural product must embrace genetics, molecular biology and enzymology whilst the biologists need the complementary strengths of the most advanced chemistry. A second theme will be to demonstrate the power of experiments, based on multiple labelling of biosynthetically generated intermediates, for studying natural pathways. The lecture will describe research involving molecular biology, enzymology, synthesis, isotopic labelling and the full panoply of modem NMR techniques.

引用

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页码：1113 / 1122

页数：10

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