INVITRO PROTEIN-SYNTHESIS IS AFFECTED BY THE HERBICIDE 2,4-DICHLOROPHENOXYACETIC ACID IN AZOSPIRILLUM-BRASILENSE

被引：12

作者：

RIVAROLA, V ^{[1
]}

FABRA, A ^{[1
]}

MORI, G ^{[1
]}

BALEGNO, H ^{[1
]}

机构：

[1] UNIV NACL RIO CUARTO, FAC CIENCIAS EXACTAS, FISICO QUIM, RA-5800 RIO CUARTO, ARGENTINA

来源：

TOXICOLOGY | 1992年 / 73卷 / 01期

关键词：

2,4-DICHLOROPHENOXYACETIC ACID (2,4-D); POLYAMINES; AZOSPIRILLUM-BRASILENSE; PROTEIN SYNTHESIS;

D O I：

10.1016/0300-483X(92)90171-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 2,4-dichlorophenoxyacetic acid (2,4-D) on growth and protein, DNA and RNA synthesis of Azospirillum brasilense Cd were studied. At a concentration of 1 mM, 2,4-D inhibited cell growth, an effect that was reversed either by transferring bacteria to a control (2,4-D-free) medium or to a 2,4-D-treated medium supplemented with polyamines. The herbicide also affected in vitro protein synthesis, either when Azospirillum brasilense Cd's own cellular mRNA or an artificial mRNA was used. This effect was also reversed by the addition of polyamines to the 2,4-D-treated medium. Similar results were observed when DNA synthesis was studied in synchronous cultures. Taking into account the effects of this herbicide on animal cells (V.A. Rivarola and H.F. Balegno, Toxicology, 68 (1991) 109) we postulate that the mechanism of action of 2,4-D is similar on both procaryotic and eucaryotic cells, probably acting through the polyamine metabolism.

引用

页码：71 / 79

页数：9

共 18 条

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