炎症性肠病的免疫治疗进展

被引:22
作者
孟松 [1 ,2 ]
吴文溪 [1 ]
机构
[1] 南京医科大学第一附属医院胃肠外科
[2] 徐州医学院附属医院普通外科
关键词
炎症性肠病; 免疫治疗;
D O I
暂无
中图分类号
R574.6 [大肠疾病];
学科分类号
100201 [内科学];
摘要
炎症性肠病(inflammatory bowel diseases,IBD)的病因和发病机制仍未完全明确。其发病与免疫、遗传、环境、微生物感染等因素均有密切的联系。传统的治疗手段包括水杨酸类制剂、糖皮质激素、免疫抑制剂、抗生素及手术切除等。根据IBD发病机制中的免疫因素,近年来免疫治疗药物试用于IBD的治疗。文中对IBD免疫治疗研究的新进展作一综述。
引用
收藏
页码:972 / 976
页数:5
相关论文
共 14 条
[1]
Infliximab as rescue therapy in severe to moderately severe ulcerative colitis:: A randomized, placebo-controlled study [J].
Järnerot, G ;
Hertervig, E ;
Friis-Liby, I ;
Blomquist, L ;
Karlé, P ;
Grännö, C ;
Vilien, M ;
Ström, M ;
Danielsson, Å ;
Verbaan, H ;
Hellström, PM ;
Magnuson, A ;
Curman, B .
GASTROENTEROLOGY, 2005, 128 (07) :1805-1811
[2]
Immunomodulatory therapy for inflammatory bowel disease [J].
Kusugami, K ;
Ina, K ;
Ando, T ;
Hibi, K ;
Nishio, Y ;
Goto, H .
JOURNAL OF GASTROENTEROLOGY, 2004, 39 (12) :1129-1137
[3]
Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis [J].
Creed, TJ ;
Norman, MR ;
Probert, CSJ ;
Harvey, RF ;
Shaw, IS ;
Smithson, J ;
Anderson, J ;
Moorghen, M ;
Gupta, J ;
Shepherd, NA ;
Dayan, CM ;
Hearing, SD .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 18 (01) :65-75
[4]
A pilot study on the use of the humanized anti–interleukin-2 receptor antibody daclizumab in active ulcerative colitis.[J].Gert Van Assche;Ignace Dalle;Maja Noman;Isolde Aerden;Caroline Swijsen;Katrien Asnong;Bart Maes;Jan Ceuppens;Karel Geboes;Paul Rutgeerts.The American Journal of Gastroenterology.2003, 2
[5]
Calcineurin inhibitors; cyclosporin A and tacrolimus inhibit expression of inducible nitric oxide synthase in colon epithelial and macrophage cell lines.[J]..European Journal of Pharmacology.2002, 2
[6]
Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis [J].
Su, CY ;
Salzberg, BA ;
Lewis, JD ;
Deren, JJ ;
Kornbluth, A ;
Katzka, DA ;
Stein, RB ;
Adler, DR ;
Lichtenstein, GR .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2002, 97 (10) :2577-2584
[7]
Effects of IL-6 variants in multiple myeloma: Growth inhibition and induction of apoptosis in primary cells [J].
Petrucci, MT ;
Ricciardi, MR ;
Gregorj, C ;
Ciapponi, L ;
Savino, R ;
Ciliberto, G ;
Tafuri, A .
LEUKEMIA & LYMPHOMA, 2002, 43 (12) :2369-2375
[8]
Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question [J].
Neurath, MF ;
Finotto, S ;
Fuss, I ;
Boirivant, M ;
Galle, PR ;
Strober, W .
TRENDS IN IMMUNOLOGY, 2001, 22 (01) :21-26
[9]
Tacrolimus in corticosteroid-resistant ulcerative colitis [J].
Matsuhashi, N ;
Nakajima, A ;
Watanabe, K ;
Komeno, Y ;
Suzuki, A ;
Ohnishi, S ;
Omata, M ;
Kondo, K ;
Usui, Y ;
Iwadare, J ;
Watanabe, T ;
Nagawa, H ;
Muto, T .
JOURNAL OF GASTROENTEROLOGY, 2000, 35 (08) :635-640
[10]
Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease [J].
Fedorak, RN ;
Gangl, A ;
Elson, CO ;
Rutgeerts, P ;
Schreiber, S ;
Wild, G ;
Hanauer, SB ;
Kilian, A ;
Cohard, M ;
LeBeaut, A ;
Feagan, B .
GASTROENTEROLOGY, 2000, 119 (06) :1473-1482