肠道微生态系统与肠黏膜免疫关系研究进展

被引：52

作者：

洪南

湛先保

机构：

[1] 第二军医大学临床二队

来源：

医学研究生学报 | 2014年 / 27卷 / 04期

关键词：

肠道微生态; 肠黏膜; 免疫; 炎症性肠病;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

肠道微生态系统参与肠黏膜免疫系统的发育,促进肠黏膜分泌型免疫球蛋白A(secreted IgA,sIgA)的合成,并与肠黏膜免疫细胞相互调节,是维持肠道稳态的重要机制,在炎症性肠病、肠易激综合征、小儿过敏性疾病等疾患的发生发展中发挥重要的作用。文中对肠道微生态系统与肠黏膜免疫功能关系的进展作一综述。

引用

页码：444 / 446

页数：3

共 14 条

[1]

The Impact of the Gut Microbiota on Human Health: An Integrative View [J].

Clemente, Jose C. ;

Ursell, Luke K. ;

Parfrey, Laura Wegener ;

Knight, Rob .

CELL, 2012, 148 (06) :1258-1270

[2]

Homeland Security: IgA immunity at the frontiers of the body [J].

Macpherson, Andrew J. ;

Geuking, Markus B. ;

McCoy, Kathy D. .

TRENDS IN IMMUNOLOGY, 2012, 33 (04) :160-167

[3]

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses [J].

Littman, Dan R. ;

Pamer, Eric G. .

CELL HOST & MICROBE, 2011, 10 (04) :311-323

[4]

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses [J].

Geuking, Markus B. ;

Cahenzli, Julia ;

Lawson, Melissa A. E. ;

Ng, Derek C. K. ;

Slack, Emma ;

Hapfelmeier, Siegfried ;

McCoy, Kathy D. ;

Macpherson, Andrew J. .

IMMUNITY, 2011, 34 (05) :794-806

[5]

Factor Analysis Demonstrates a Symptom Cluster Related to Methane and Non-methane Production in Irritable Bowel Syndrome [J].

Makhani, Marc ;

Yang, Janet ;

Mirocha, James ;

Low, Kimberly ;

Pimentel, Mark .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2011, 45 (01) :40-44

[6]

The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut [J].

Suzuki, Keiichiro ;

Maruya, Mikako ;

Kawamoto, Shimpei ;

Sitnik, Katarzyna ;

Kitamura, Hiroshi ;

Agace, William W. ;

Fagarasan, Sidonia .

IMMUNITY, 2010, 33 (01) :71-83

[7]

Microbiota-stimulated immune mechanisms to maintain gut homeostasis [J].

Chung, Hachung ;

Kasper, Dennis Lee .

CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (04) :455-460

[8]

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine [J].

Cadwell, Ken ;

Patel, Khushbu K. ;

Maloney, Nicole S. ;

Liu, Ta-Chiang ;

Ng, Aylwin C. Y. ;

Storer, Chad E. ;

Head, Richard D. ;

Xavier, Ramnik ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

CELL, 2010, 141 (07) :1135-U64

[9]

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation [J].

Littman, Dan R. ;

Rudensky, Alexander Y. .

CELL, 2010, 140 (06) :845-858

[10]

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis.[J].Sidonia Fagarasan;Shimpei Kawamoto;Osami Kanagawa;Keiichiro Suzuki.Annual Review of Immunology.2010, 1

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