Wnt/β-catenin信号通路与器官纤维化的关系

被引：13

作者：

石春花

石明隽

王圆圆

肖瑛

张昌志

孙兰

郭兵

机构：

[1] 贵阳医学院病理生理学教研室

来源：

贵阳医学院学报 | 2015年 / 40卷 / 04期

关键词：

Wnt; β-catenin; 信号传导; 纤维化;

D O I：

10.19367/j.cnki.1000-2707.2015.04.001

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

<正>Wnt基因是一种原癌基因,1982年Nusse等[1]在用小鼠乳头瘤病毒(mouse mammary tumor virus,MMTV)诱导小鼠乳腺癌过程中发现了Wnt基因,由于该基因的激活依赖MMTV的插入(insertion),因此被命名为Int-1。后研究发现Int-1基因与1973年Sharma报道的果蝇的无翅基因Wingless(wg)为同源基因,因此将两者合并称为Wnt基

引用

收藏

页码：325 / 329+336 +336

页数：6

相关论文

共 10 条

[1]

The way Wnt works: Components and mechanism [J].

Saito-Diaz, Kenyi ;

Chen, Tony W. ;

Wang, Xiaoxi ;

Thorne, Curtis A. ;

Wallace, Heather A. ;

Page-McCaw, Andrea ;

Lee, Ethan .

GROWTH FACTORS, 2013, 31 (01) :1-31

[2]

Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential [J].

Dawson, Kristin ;

Aflaki, Mona ;

Nattel, Stanley .

JOURNAL OF PHYSIOLOGY-LONDON, 2013, 591 (06) :1409-1432

[3]

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6 [J].

Ahn, Victoria E. ;

Chu, Matthew Ling-Hon ;

Choi, Hee-Jung ;

Tran, Denise ;

Abo, Arie ;

Weis, William I. .

DEVELOPMENTAL CELL, 2011, 21 (05) :862-873

[4]

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases [J].

MacDonald, Bryan T. ;

Tamai, Keiko ;

He, Xi .

DEVELOPMENTAL CELL, 2009, 17 (01) :9-26

[5]

Wnt signaling enhances the activation and survival of human hepatic stellate cells [J].

Myung, Sun Jung ;

Yoon, Jung-Hwan ;

Gwak, Geum-Youn ;

Kim, Won ;

Lee, Jeong-Hoon ;

Kim, Kang Mo ;

Shin, Chan Soo ;

Jang, Ja June ;

Lee, Sung-Hee ;

Lee, Soo-Mi ;

Lee, Hyo-Suk .

FEBS LETTERS, 2007, 581 (16) :2954-2958

[6]

A Second Canon.[J].Michael T Veeman;Jeffrey D Axelrod;Randall T Moon.Developmental Cell.2003, 3

[7]

The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation [J].

Zeng, L ;

Fagotto, F ;

Zhang, T ;

Hsu, W ;

Vasicek, TJ ;

Perry, WL ;

Lee, JJ ;

Tilghman, SM ;

Gumbiner, BM ;

Costantini, F .

CELL, 1997, 90 (01) :181-192

[8]

Cadherins and catenins in development [J].

Huber, O ;

Bierkamp, C ;

Kemler, R .

CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (05) :685-691

[9]

Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays [J].

Xiong, Wu-Jun ;

Hu, Li-Juan ;

Jian, Yi-Cheng ;

Wang, Li-Jing ;

Jiang, Ming ;

Li, Wei ;

He, Yi .

WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (15) :1745-1752

[10]

Wnt/β-catenin信号途径在高糖诱导肾小管上皮细胞转分化中的作用 [J].

闫喆 ;

姚芳 ;

段惠军 ;

谭会斌 ;

张春霞 ;

邢玲玲 .

中国组织化学与细胞化学杂志, 2009, 18 (04) :396-400