Molecular insights to therapeutic in cancer: role of exosomes in tumor microenvironment, metastatic progression and drug resistance

被引：16

作者：

Panda, Shikshya S. ^{[1
]}

Sahoo, Rajeev K. ^{[1
]}

Patra, Sambit K. ^{[1
]}

Biswal, Stuti ^{[1
]}

Biswal, Bijesh K. ^{[1
]}

机构：

[1] Natl Inst Technol Rourkela, Dept Life Sci, Canc Drug Resistance Lab, Rourkela 769008, Odisha, India

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 08期

关键词：

Cancer; exosome; tumor microenvironment; tumor heterogeneity; metastasis; drug resistance; BREAST-CANCER; MACROPHAGES; SUPPRESSION; DELIVERY; CELLS;

D O I：

10.1016/j.drudis.2024.104061

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Exosomes play a pivotal part in cancer progression and metastasis by transferring various biomolecules. Recent research highlights their involvement in tumor microenvironment remodeling, mediating metastasis, tumor heterogeneity and drug resistance. The unique cargo carried by exosomes garners the interest of researchers owing to its potential as a stage-specific biomarker for early cancer detection and its role in monitoring personalized treatment. However, unanswered questions hinder a comprehensive understanding of exosomes and their cargo in this context. This review discusses recent advancements and proposes novel ideas for exploring exosomes in cancer progression, aiming to deepen our understanding and improve treatment approaches.

引用

收藏

页数：15

相关论文

共 138 条

[41]

Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches [J].

Jahangiri, Babak ;

Saei, Ali Kian ;

Obi, Patience O. ;

Asghari, Narjes ;

Lorzadeh, Shahrokh ;

Hekmatirad, Shirin ;

Rahmati, Marveh ;

Velayatipour, Fatemeh ;

Asghari, Mohammad Hosseni ;

Saleem, Ayesha ;

Moosavi, Mohammad Amin .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2022, 1868 (10)

[42]

Small extracellular vesicle-mediated metabolic reprogramming: from tumors to pre-metastatic niche formation [J].

Jiang, Chuwen ;

Jiang, Zhengting ;

Sha, Gengyu ;

Wang, Daorong ;

Tang, Dong .

CELL COMMUNICATION AND SIGNALING, 2023, 21 (01)

[43]

Exosomes Regulate the Epithelial-Mesenchymal Transition in Cancer [J].

Jiang, Jingwen ;

Li, Jiayu ;

Zhou, Xiumei ;

Zhao, Xueqin ;

Huang, Biao ;

Qin, Yuan .

FRONTIERS IN ONCOLOGY, 2022, 12

[44]

Exosomal lincROR Promotes Docetaxel Resistance in Prostate Cancer through a β-catenin/HIF1α Positive Feedback Loop [J].

Jiang, Xingkang ;

Xu, Yong ;

Liu, Ranlu ;

Guo, Shanqi .

MOLECULAR CANCER RESEARCH, 2023, 21 (05) :472-482

[45]

Exosomes in the tumor microenvironment: Promoting cancer progression [J].

Jin, Ye ;

Xing, Jianming ;

Xu, Kejin ;

Liu, Da ;

Zhuo, Yue .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[46]

The biology, function, and biomedical applications of exosomes [J].

Kalluri, Raghu ;

LeBleu, Valerie S. .

SCIENCE, 2020, 367 (6478) :640-+

[47]

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics [J].

Kar, Rishav ;

Dhar, Rajib ;

Mukherjee, Sayantanee ;

Nag, Sagnik ;

Gorai, Sukhamoy ;

Mukerjee, Nobendu ;

Mukherjee, Dattatreya ;

Vatsa, Rishabh ;

Jadhav, Mamtha Chandrakanth ;

Ghosh, Arabinda ;

Devi, Arikketh ;

Krishnan, Anand ;

Thorat, Nanasaheb D. .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2023, 9 (02) :577-594

[48]

Exosomes and the extracellular matrix: a dynamic interplay in cancer progression [J].

Karampoga, Asimina ;

Tzaferi, Kyriaki ;

Koutsakis, Christos ;

Kyriakopoulou, Konstantina ;

Karamanos, Nikos K. .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2022, 66 (1-3) :97-102

[49]

The Emerging Roles of Exosomes as EMT Regulators in Cancer [J].

Kim, Hyunwoo ;

Lee, Sungmin ;

Shin, Eunguk ;

Seong, Ki Moon ;

Jin, Young Woo ;

Youn, HyeSook ;

Youn, BuHyun .

CELLS, 2020, 9 (04)

[50]

Theranostic signature of tumor-derived exosomes in cancer [J].

Kumar, Samruti ;

Dhar, Rajib ;

Kumar, Lokesh Babu Sirkali Suresh ;

Shivji, Gauresh Gurudas ;

Jayaraj, Rama ;

Devi, Arikketh .

MEDICAL ONCOLOGY, 2023, 40 (11)

← 1 2 3 4 5 6 7 8 9 10 →