Tunable c-MYC LNA i-motif

被引：18

作者：

Kumar, Niti ^{[1
]}

Petersen, Michael ^{[2
]}

Maiti, Souvik ^{[1
]}

机构：

[1] CSIR, Struct Biol Unit, Inst Genom & Integrat Biol, Delhi 110007, India

[2] Univ So Denmark, Nucle Acid Ctr, Dept Chem & Phys, DK-5230 Odense M, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 12期

关键词：

DRIVEN CONFORMATIONAL SWITCH; COMPLEMENTARY STRAND; TETRAPLEX FORMATION; SMALL-MOLECULE; G-QUADRUPLEX; RICH STRAND; DNA; PROMOTER; THERMODYNAMICS; BINDING;

D O I：

10.1039/b819305c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using spectroscopic techniques, we demonstrate the effect of LNA (locked nucleic acid) nucleotides in modulating the formation and stability of the i-motif structure formed by the c-MYC sequence.

引用

页码：1532 / 1534

页数：3

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