吲哚胺2,3-双加氧化酶1及其抑制剂的研究

被引：6

作者：

张胜男

刘鑫

杨青

机构：

[1] 复旦大学生命科学学院生物化学系

来源：

复旦学报(医学版) | 2017年 / 01期

基金：

高等学校博士学科点专项科研基金;

关键词：

吲哚胺2,3-双加氧酶1; 抑制剂; 肿瘤免疫治疗;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

吲哚胺2,3-双加氧化酶1(indoleamine 2,3-dioxygenase 1,IDO1)是肝脏以外催化色氨酸沿着犬尿氨酸途径(kynurenine pathway,KP)分解代谢的限速酶。IDO1过度活化而引起KP的神经毒性产物喹啉酸(quinolinic acid,QUIN)的蓄积,是导致神经紊乱和神经退行性疾病的重要原因。IDO1同时又是免疫耐受酶,在诱导母胎免疫耐受和肿瘤免疫逃逸中均发挥重要作用,被视为新的免疫检查点。IDO1与阿尔茨海默病、老年性白内障、癌症等多种疾病发病机制的相关性已被证实,因此IDO1抑制剂作为极具潜能的药物受到日益广泛的关注。本文就IDO1的生物活性及其抑制剂的研究作一综述。

引用

页码：1 / 7

页数：7

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