Hedgehog信号通路在肿瘤中作用的研究进展

被引：4

作者：

李晓伟

刘炳亚

机构：

[1] 上海交通大学医学院附属瑞金医院外科上海消化外科研究所

来源：

生命科学 | 2009年 / 21卷 / 01期

关键词：

hedgehog信号通路; PTCH; SMO; Gli; 肿瘤;

D O I：

10.13376/j.cbls/2009.01.031

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

癌的发生是一个多因素多步骤的过程,同时伴随着一系列致癌因素所导致的基因突变,以及某些信号通路的异常激活。hedgehog(HH)信号通路参与了正常的胚胎发育过程以及组织的创伤与修复,特别是干细胞的自我更新,但它的异常激活却在多种人类恶性肿瘤中有发生。本文集中介绍HH在癌的发生、增殖、浸润及转移中所起的重要作用,通过对其致癌机制的综述,阐明它将可能成为一个有效治疗靶点,从而为肿瘤的防治提供了更多机遇。

引用

页码：116 / 121

页数：6

共 17 条

[1] Regulation of in situ to invasive breast carcinoma transition [J].

Hu, Min ;

Yao, Jun ;

Carroll, Danielle K. ;

Weremowicz, Stanislawa ;

Chen, Haiyan ;

Carrasco, Daniel ;

Richardson, Andrea ;

Violette, Shelia ;

Nikolskaya, Tatiana ;

Nikolsky, Yuri ;

Bauerlein, Erica L. ;

Hahn, William C. ;

Gelman, Rebecca S. ;

Allred, Craig ;

Bissell, Mina J. ;

Schnitt, Stuart ;

Polyak, Kornelia .

CANCER CELL, 2008, 13 (05) :394-406

[2]

Primers on Molecular Pathways GLI: More than Just Hedgehog?[J] . Martín E. Fernández-Zapico.Pancreatology . 2008 (3)

[3]

Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma[J] . Mehdi Shahi,Aiala Lorente,Javier Castresana.Oncology Reports . 2008 (3)

[4] Control of antagonistic components of the hedgehog signaling pathway by microRNAs in Drosophila [J].

Friggi-Grelin, Florence ;

Lavenant-Staccini, Laurence ;

Therond, Pascal .

GENETICS, 2008, 179 (01) :429-439

[5] New drugs in the treatment of gastric tumors [J].

Abad A. .

Clinical and Translational Oncology, 2008, 10 (5) :256-261

[6] Developmental signaling pathways in brain tumor-derived stem-like cells [J].

Clark, Paul A. ;

Treisman, Daniel M. ;

Ebben, Johnathan ;

Kuo, John S. .

DEVELOPMENTAL DYNAMICS, 2007, 236 (12) :3297-3308

[7]

Non-Canonical Activation of GLI Transcription Factors: Implications for Targeted Anti-Cancer Therapy[J] . Matthias Lauth,Rune Toftg?rd.Cell Cycle . 2007 (20)

[8] Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity [J].