结缔组织生长因子在肾间质纤维化中的表达及其调控

被引：1

作者：

刘燕

樊均明

机构：

[1] 四川大学华西医院肾内科,四川大学华西医院肾内科四川成都,四川成都

来源：

中国病理生理杂志 | 2004年 / 09期

关键词：

结缔组织生长因子; 转化生长因子β; 肾间质纤维化;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

1002 ; 100210 ;

摘要：

CTGF, a member of the CCN family of immediate early genes, is a recently discovered profibrotic growth factor, which is involved in many pathophysiologic procedures. CTGF acts as a downstream effector of TGF-β acting on interstitial cells to enhance the progression of fibrotic renal diseases. It has been shown that CTGF gene expression can be induced or blocked by some kinds of cytokine and drugs. It is an interesting candidate target for future intervention strategies of renal interstitial fibrosis. [

引用

页码：189 / 192

页数：4

共 7 条

[1] 尿本周氏蛋白及转化生长因子β1对肾近端小管上皮细胞增殖的影响 [J].