急性缺血性脑卒中静脉溶栓后出血性转化危险因素分析

被引：35

作者：

黄银辉 ^{[1
]}

李明媚 ^{[2
]}

陈振杰 ^{[2
]}

林友榆 ^{[1
]}

欧阳宛炯 ^{[3
]}

卓识途 ^{[3
]}

蔡若蔚 ^{[3
]}

机构：

[1] 福建省晋江市医院神经内科

[2] 福建省安溪县铭选医院神经内科

[3] 福建医科大学附属第二医院神经内科

来源：

中国神经精神疾病杂志 | 2013年 / 39卷 / 10期

关键词：

静脉溶栓; 急性缺血性脑卒中; 出血性转化; 因素;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

目的探讨急性缺血性脑卒中患者静脉溶栓后出血性转化(hemorrhagic transformation,HT)的危险因素。方法回顾性分析接受静脉溶栓治疗的171例急性缺血性脑卒中患者按治疗后7 d内行头颅CT检查,根据头颅有无出血性转化分为HT组及无HT组,比较两组患者的临床资料,采用单因素和Logistic回归分析静脉溶栓治疗后出血性转化的危险因素。结果HT组(33例)与无HT组(138例)相比,既往有糖尿病者较多(P=0.008),溶栓前头颅CT有早期缺血改变者较多(P=0.040),溶栓前美国卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分较高(P=0.033),起病-溶栓时间(onset to treatment time,OTT)较长(P=0.043),溶栓后2 h收缩压、24 h收缩压、24 h舒张压较高(P=0.008、P=0.049、P=0.002)。Logistic回归分析表明溶栓前头颅CT有早期缺血改变者、溶栓前NIHSS评分高、溶栓后2 h及24 h收缩压高者与溶栓后HT发生显著相关。结论溶栓前头颅CT有早期缺血改变、溶栓前NIHSS评分的分值偏高、溶栓后2 h及24 h收缩压偏高是溶栓后HT的危险因素。

引用

页码：581 / 586

页数：6

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