急性基底动脉闭塞溶栓早期临床预后分析

被引:9
作者
徐安定
唐敬敬
李牧
辛秀峰
杨万勇
刘小艳
机构
[1] 暨南大学脑科学研究所暨南大学附属第一医院神经内科
关键词
急性基底动脉闭塞; 溶栓; 早期预后;
D O I
暂无
中图分类号
R743.32 [脑血栓形成];
学科分类号
摘要
目的评估急性基底动脉闭塞(basilar artery occlusion,BAO)患者溶栓后早期临床预后及其影响因素。方法总结我院2003年至2011年15例急性BAO溶栓患者资料,分析其早期预后及影响因素。其中早期不良预后指标为出院时死亡或植物生存,早期良好预后指标为改良Rankin评分0~2分。结果 15例急性BAO溶栓患者,重组组织型纤溶酶原激活剂动脉溶栓8例、静脉溶栓4例,尿激酶动脉溶栓2例、动静脉联合溶栓1例。其中早期不良预后6例(40%)、早期良好预后5例(33%),与国内外报道最佳结果相近。发生2例症状性颅内出血,均死亡。早期不良预后者年龄和基线收缩压明显高于对照组(76±5岁,64±11岁,P=0.011;171±18 mmHg,145±22 mmHg,P=0.039),基线神经功能缺损评分更高(NIHSS 29.2±9.2,17.9±11.5),发病至溶栓时间更长(中位时间82.79 h,9.00 h),二者均接近统计学差异边缘(P=0.077)。结论急性BAO患者应尽可能溶栓;症状性颅内出血、高龄、高基线血压和神经功能缺损评分、发病至溶栓时间延长与其早期不良预后可能有关。
引用
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页码:289 / 293
页数:5
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