热休克蛋白70的结构和功能

被引：127

作者：

王宇萍

蒋建东

机构：

[1] 中国医学科学院医药生物技术研究所

来源：

中国细胞生物学学报 | 2010年 / 32卷 / 02期

关键词：

热休克蛋白70; 分子伴侣; 生物学功能;

D O I：

暂无

中图分类号：

Q51 [蛋白质];

学科分类号：

070307 [化学生物学];

摘要：

热休克蛋白70(HSP70)是进化上高度保守的一种的蛋白质,具有多种生物学功能,包括分子伴侣功能,具有细胞保护及抗细胞凋亡功能,参与免疫调节,以及在病毒感染与疾病研究中也有重要作用。本文着重对HSP70的结构和功能研究的进展作一综述。

引用

收藏

页码：305 / 313

页数：9

相关论文

共 12 条

[1]

The Heat Shock Cognate Protein 70 Is Associated with Hepatitis C Virus Particles and Modulates Virus Infectivity [J].

Parent, Romain ;

Qu, Xiaoyu ;

Petit, Marie-Anne ;

Beretta, Laura .

HEPATOLOGY, 2009, 49 (06) :1798-1809

[2]

The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system [J].

Franklin, TB ;

Krueger-Naug, AM ;

Clarke, DB ;

Arrigo, AP ;

Currie, RW .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2005, 21 (05) :379-392

[3]

Augmentation of DNA vaccine potency through secretory heat shock protein-mediated antigen targeting [J].

Hauser, H ;

Chen, SY .

METHODS, 2003, 31 (03) :225-231

[4]

Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways [J].

Parcellier, A ;

Gurbuxani, S ;

Schmitt, E ;

Solary, E ;

Garrido, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (03) :505-512

[5]

Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients [J].

Zhong, L ;

Peng, XJ ;

Hidalgo, GE ;

Doherty, DE ;

Stromberg, AJ ;

Hirschowitz, EA .

CANCER DETECTION AND PREVENTION, 2003, 27 (04) :285-290

[6]

Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer [J].

Kanazawa, Y ;

Isomoto, H ;

Oka, M ;

Yano, Y ;

Soda, H ;

Shikuwa, S ;

Takeshima, F ;

Omagari, K ;

Mizuta, Y ;

Murase, K ;

Nakagoe, T ;

Ohtsuka, K ;

Kohno, S .

MEDICAL ONCOLOGY, 2003, 20 (02) :157-164

[7]

Heat-shock proteins as activators of the innate immune system [J].

Wallin, RPA ;

Lundqvist, A ;

Moré, SH ;

von Bonin, A ;

Kiessling, R ;

Ljunggren, HG .

TRENDS IN IMMUNOLOGY, 2002, 23 (03) :130-135

[8]

HBV-specific peptide associated with heat-shock protein gp96 [J].

Meng, SD ;

Gao, T ;

Gao, GF ;

Tien, P .

LANCET, 2001, 357 (9255) :528-529

[9]

Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids [J].

Hu, JM ;

Toft, DO ;

Seeger, C .

EMBO JOURNAL, 1997, 16 (01) :59-68

[10]

HEAT-SHOCK PROTEINS ARE DIFFERENTIALLY EXPRESSED IN HUMAN GASTROINTESTINAL CANCERS [J].

EHRENFRIED, JA ;

HERRON, BE ;

TOWNSEND, CM ;

EVERS, BM .

SURGICAL ONCOLOGY-OXFORD, 1995, 4 (04) :197-203