孤独症的发病与遗传基因的关系

被引:3
作者
静进
机构
[1] 中山大学公共卫生学院妇幼卫生系
关键词
孤独症谱系障碍; 遗传学; 候选基因;
D O I
暂无
中图分类号
R749.94 [儿童精神病];
学科分类号
100205 ;
摘要
有关孤独症谱系障碍(autism spectrum disorder,ASD)的遗传学研究进展迅速,国际上发表的相关论文日趋增多,研究陆续发现了许多与发病相关的染色体或候选基因,其中15号染色体、X染色体以及7号染色体异常或相关的某些区段的基因变异报道较多,但亦有许多相矛盾的研究结果。整理和介绍一些重要的文献内容,可能益于国内同仁做研究参考,故将近期相关研究做一介绍。
引用
收藏
页码:555 / 557
页数:3
相关论文
共 9 条
[1]   Hyperserotonemia in adults with autistic disorder [J].
Hranilovic, Dubravka ;
Bujas-Petkovic, Zorana ;
Vragovic, Renata ;
Vuk, Tomislav ;
Hock, Karlo ;
Jernej, Branimir .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2007, 37 (10) :1934-1940
[2]   Hyperserotoninemia and altered immunity in autism [J].
Burgess, Nancy K. ;
Sweeten, Thayne L. ;
McMahon, William M. ;
Fujinami, Robert S. .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2006, 36 (05) :697-704
[3]  
En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder[J] . Michelle A. Cheh,James H. Millonig,Lauren M. Roselli,Xue Ming,Erin Jacobsen,Silky Kamdar,George C. Wagner.Brain Research . 2006 (1)
[4]  
The neuroligin and neurexin families: from structure to function at the synapse[J] . M-F. Lisé,A. El-Husseini.Cellular and Molecular Life Sciences . 2006 (16)
[5]   Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population [J].
Wu, SP ;
Jia, MX ;
Ruan, Y ;
Liu, J ;
Guo, YQ ;
Shuang, M ;
Gong, XH ;
Zhang, YB ;
Yang, XL ;
Zhang, D .
BIOLOGICAL PSYCHIATRY, 2005, 58 (01) :74-77
[6]   Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus [J].
Benayed, R ;
Gharani, N ;
Rossman, I ;
Mancuso, V ;
Lazar, G ;
Kamdar, S ;
Bruse, SE ;
Tischfield, S ;
Smith, BJ ;
Zimmerman, RA ;
DiCicco- Bloom, E ;
Brzustowicz, LM ;
Millonig, JH .
AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (05) :851-868
[7]   Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism [J].
Ma, DQ ;
Whitehead, PL ;
Menold, MM ;
Martin, ER ;
Ashley-Koch, AE ;
Mei, H ;
Ritchie, MD ;
DeLong, GR ;
Abramson, RK ;
Wright, HH ;
Cuccaro, ML ;
Hussman, JP ;
Gilbert, JR ;
Pericak-Vance, MA .
AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (03) :377-388
[8]  
Replication of Autism Linkage: Fine-Mapping Peak at 17q21[J] . Rita M. Cantor,Naoko Kono,Jackie A. Duvall,Ana Alvarez-Retuerto,Jennifer L. Stone,Maricela Alarcón,Stanley F. Nelson,Daniel H. Geschwind.The American Journal of Human Genetics . 2005 (6)
[9]   No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population [J].
Marui, T ;
Koishi, S ;
Funatogawa, I ;
Yamamoto, K ;
Matsumoto, H ;
Hashimoto, O ;
Nanba, E ;
Kato, C ;
Ishijima, M ;
Watanabe, K ;
Kasai, K ;
Kato, N ;
Sasaki, T .
NEUROSCIENCE RESEARCH, 2005, 53 (01) :91-94