No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population

被引：23

作者：

Marui, T

Koishi, S

Funatogawa, I

Yamamoto, K

Matsumoto, H

Hashimoto, O

Nanba, E

Kato, C

Ishijima, M

Watanabe, K

Kasai, K

Kato, N

Sasaki, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Tokai Univ, Sch Med, Dept Psychiat, Isehara, Kanagawa 25911, Japan

[3] Univ Tokyo, Sch Hlth Sci & Nursing, Dept Biostat, Tokyo, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan

[5] Tottori Univ, Gene Res Ctr, Yonago, Tottori 683, Japan

[6] Univ Tokyo, Hlth Serv Ctr, Dept Psychiat, Tokyo 113, Japan

来源：

NEUROSCIENCE RESEARCH | 2005年 / 53卷 / 01期

关键词：

autism; chromosome; 7q; FOXP2; PTPRZ1; genetic association;

D O I：

10.1016/j.neures.2005.05.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism is a child-onset pervasive developmental disorder, with a significant role of genetic factors in its development. Genome-wide linkage studies have suggested a 7q region as a susceptibility locus for autism. We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls. No significant difference was observed, after correction for the multiple testing, in allele, genotype or haplotype frequencies of the SNPs of FOXP2 or PTPRZ1 between patients and controls. No evidence was thus obtained for a major role of FOXP2 or PTPRZ1 in the development of autism. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：91 / 94

页数：4

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