TSC-mTOR信号通路在糖尿病及糖尿病肾病发病机制中的作用

被引:7
作者
王洋
夏宁
机构
[1] 广西医科大学第二附属医院代谢糖尿病科
关键词
糖尿病; 糖尿病肾病; TSC-mTOR;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
摘要
引用
收藏
页码:354 / 358
页数:5
相关论文
共 9 条
[1]   胰岛素抵抗与糖尿病肾病的关系 [J].
刘红燕 ;
林碧 ;
余劲明 .
广西医学, 2005, (12) :1920-1922
[2]   The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential [J].
Mori, Hiroyuki ;
Inoki, Ken ;
Masutani, Kohsuke ;
Wakabayashi, Yu ;
Komai, Kyoko ;
Nakagawa, Ryusuke ;
Guan, Kun-Liang ;
Yoshimura, Akihiko .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 384 (04) :471-475
[3]   Rapamycin Prevents and Breaks the Anti-CD3-Induced Tolerance in NOD Mice [J].
Valle, Andrea ;
Jofra, Tatiana ;
Stabilini, Angela ;
Atkinson, Mark ;
Roncarolo, Maria-Grazia ;
Battaglia, Manuela .
DIABETES, 2009, 58 (04) :875-881
[4]   Rapamycin impairs β-cell proliferation in vivo [J].
Zahr, E. ;
Molano, R. D. ;
Pileggi, A. ;
Ichii, H. ;
Jose, S. San ;
Bocca, N. ;
An, W. ;
Gonzalez-Quintana, J. ;
Fraker, C. ;
Ricordi, C. ;
Inverardi, L. .
TRANSPLANTATION PROCEEDINGS, 2008, 40 (02) :436-437
[5]  
Role of TSC–mTOR pathway in diabetic nephropathy[J] . Ken Inoki.Diabetes Research and Clinical Practice . 2008
[6]  
mTOR Inhibition by Rapamycin Prevents[beta]-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes[J] . Fraenkel,Merav,Ketzinel-Gilad,Mali,Ariav,Yafa,Pappo,Orit,Karaca,Melis,Castel,Julien,Berthault,Marie-France,Magnan,Christophe,Cerasi,Erol,Kaiser,Nurit,Leibowitz,Gil.Diabetes . 2008 (4)
[7]   Growing roles for the mTOR pathway [J].
Sarbassov, DD ;
Ali, SM ;
Sabatini, DM .
CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (06) :596-603
[8]  
MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632[J] . P. Gual,T. Grémeaux,T. Gonzalez,Y. Marchand-Brustel,J.-F. Tanti.Diabetologia . 2003 (11)
[9]  
Insulinreceptors inβ-cells are critical for islet compensatory growthresponse toinsulin resistance .2 Okada T,LiewCW,Hu J,et al. PNAS . 2007