代谢性疾病中胆汁酸水平变化及相关治疗策略

被引：21

作者：

况俊良

郑晓皎

赵爱华

贾伟

机构：

[1] 上海交通大学附属第六人民医院转化医学中心

来源：

上海交通大学学报(医学版) | 2019年 / 39卷 / 06期

关键词：

胆汁酸; 代谢性疾病; 法尼醇X受体; G蛋白偶联胆汁酸受体1; 生物标志物;

D O I：

暂无

中图分类号：

R589 [代谢病];

学科分类号：

100201 [内科学];

摘要：

胆汁酸作为一种信号分子可以特异性地与胆汁酸受体(如法尼醇X受体、G蛋白偶联胆汁酸受体1)结合介导一系列生物调节反应。近年发现,胆汁酸在调节糖代谢、脂质代谢和能量代谢中扮演着十分重要的角色。在代谢性疾病的发生发展过程中,也常伴随着胆汁酸谱以及受体的改变。基于胆汁酸在代谢性疾病中的重要性,未来其可能成为临床诊断、预测、评价治疗效果的潜在生物标志物。该文对胆汁酸与代谢性疾病关系以及基于调节胆汁酸代谢治疗代谢性疾病进行综述。

引用

页码：678 / 683

页数：6

共 26 条

[1]

Definitive profiling of plasma bile acids as potential biomarkers for human liver diseases using UPLC–HRMS.[J].Yao Shi;Yang Gao;Michael Van Parys;Dennis Miller;Dennis Milanowski;Brian Dean;Xiaorong Liang.Bioanalysis.2018, 12

[2]

Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice.[J].Xiaojiao Zheng;Fengjie Huang;Aihua Zhao;Sha Lei;Yunjing Zhang;Guoxiang Xie;Tianlu Chen;Chun Qu;Cynthia Rajani;Bing Dong;Defa Li;Wei Jia.BMC Biology.2017, 1

[3]

The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity [J].

Lei, Sha ;

Huang, Fengjie ;

Zhao, Aihua ;

Chen, Tianlu ;

Chen, Wenlian ;

Xie, Guoxiang ;

Zheng, Xiaojiao ;

Zhang, Yunjing ;

Yu, Haoyong ;

Zhang, Pin ;

Rajani, Cynthia ;

Bao, Yuqian ;

Jia, Weiping ;

Jia, Wei .

FASEB JOURNAL, 2017, 31 (09) :3904-3912

[4]

Bile acid control of metabolism and inflammation in obesity; type 2 diabetes; dyslipidemia and NAFLD.[J].Oscar Chávez-Talavera;Anne Tailleux;Philippe Lefebvre;Bart Staels.Gastroenterology.2017, 7

[5]

Bile acid sequestrants for glycemic control in patients with type 2 diabetes: A systematic review with meta-analysis of randomized controlled trials [J].

Hansen, Morten ;

Sonne, David P. ;

Mikkelsen, Kristian H. ;

Gluud, Lise Lotte ;

Vilsboll, Tina ;

Knop, Filip K. .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, 31 (05) :918-927

[6]

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial [J].

Risstad, Hilde ;

Kristinsson, Jon A. ;

Fagerland, Morten W. ;

le Roux, Carel W. ;

Birkeland, Kare I. ;

Gulseth, Hanne L. ;

Thorsby, Per M. ;

Vincent, Royce P. ;

Engstrom, My ;

Olbers, Torsten ;

Mala, Tom .

SURGERY FOR OBESITY AND RELATED DISEASES, 2017, 13 (09) :1544-1554

[7]

Bile Acids Increase Independently From Hypocaloric Restriction After Bariatric Surgery [J].

Jahansouz, Cyrus ;

Xu, Hongliang ;

Hertzel, Ann V. ;

Serrot, Federico J. ;

Kvalheim, Nicholas ;

Cole, Abigail ;

Abraham, Anasooya ;

Luthra, Girish ;

Ewing, Kristin ;

Leslie, Daniel B. ;

Bernlohr, David A. ;

Ikramuddin, Sayeed .

ANNALS OF SURGERY, 2016, 264 (06) :1022-1028

[8]

Fibroblast Growth Factor 21 Correlates with Weight Loss After Vertical Sleeve Gastrectomy in Adolescents [J].

Khan, Farooq H. ;

Shaw, Lindsey ;

Zhang, Wujuan ;

Gonzalez, Rosa Maria Salazar ;

Mowery, Sarah ;

Oehrle, Melissa ;

Zhao, Xueheng ;

Jenkins, Todd ;

Setchell, Kenneth D. R. ;

Inge, Thomas H. ;

Kohli, Rohit .

Obesity, 2016, 24 (11) :2377-2383

[9]

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice.[J].Anuradha Rao;Astrid Kosters;Jamie E. Mells;Wujuan Zhang;Kenneth D. R. Setchell;Angelica M. Amanso;Grace M. Wynn;Tianlei Xu;Brad T. Keller;Hong Yin;Sophia Banton;Dean P. Jones;Hao Wu;Paul A. Dawson;Saul J. Karpen.Science Translational Medicine.2016, 357

[10]

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology [J].

Perino, Alessia ;

Schoonjans, Kristina .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2015, 36 (12) :847-857

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