TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

被引：143

作者：

Perino, Alessia ^{[1
]}

Schoonjans, Kristina ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Metab Signaling, CH-1015 Lausanne, Switzerland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2015年 / 36卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

BILE-ACID RECEPTOR; ADIPOSE-TISSUE; GPBAR1; TGR5; INTESTINAL MACROPHAGES; INFLAMMATORY CYTOKINES; MEMBRANE-RECEPTOR; POTENT AGONISTS; OBESITY; DERIVATIVES; GUT;

D O I：

10.1016/j.tips.2015.08.002

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

In the past decade substantial progress has been made in understanding how the insurgence of chronic low-grade inflammation influences the physiology of several metabolic diseases. Tissue-resident immune cells have been identified as central players in these processes, linking inflammation to metabolism. The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and its activation mediates potent anti-inflammatory effects. Herein, we summarize recent advances in TGR5 research, focusing on the downstream effector pathways that are modulated by TGR5 activators, and on its therapeutic potential in inflammatory and metabolic diseases.

引用

页码：847 / 857

页数：11

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